Pereverzeva V V, Solovenchuk L L
Institute of Biological Problems of the North, Russian Academy of Sciences, Magadan, Russia.
Genetika. 1999 Apr;35(4):504-8.
Frequency distribution patterns of the HLA antigens, genes, and haplotypes at subloci A, B, and Cw were examined in 664 female and 765 male Slavs in dependence to the duration of their residence in the extreme conditions of the Magadan region. In the groups studied, no statistically significant differences in the frequencies of the corresponding genes and antigens were found. Analysis of gamete associations showed that positive and negative associations revealed in some cases were typical of the population of the region on the whole. However, sex-dependent association, as well as that dependent on the duration of residence in extreme conditions were also established.
在664名女性和765名男性斯拉夫人中，研究了HLA抗原、基因和单倍型在A、B和Cw亚位点的频率分布模式，这些斯拉夫人居住在马加丹地区的极端条件下，研究依据他们在该地区的居住时长。在所研究的群体中，未发现相应基因和抗原频率存在统计学上的显著差异。配子关联分析表明，在某些情况下发现的正向和负向关联是该地区总体人群的典型特征。然而，也确定了性别依赖性关联以及依赖于在极端条件下居住时长的关联。
