[Frequency distribution patterns of HLA antigens, genes, and haplotypesin the migrant population of northwestern Russia in relation to time of residence in the region and sex differentiation].

Frequency distribution patterns of the HLA antigens, genes, and haplotypes at subloci A, B, and Cw were examined in 664 female and 765 male Slavs in dependence to the duration of their residence in the extreme conditions of the Magadan region. In the groups studied, no statistically significant differences in the frequencies of the corresponding genes and antigens were found. Analysis of gamete associations showed that positive and negative associations revealed in some cases were typical of the population of the region on the whole. However, sex-dependent association, as well as that dependent on the duration of residence in extreme conditions were also established.