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[马加丹移民群体中HLA抗原、基因和单倍型的频率分布与在该地区居住时长的关系]

[Frequency distribution of HLA-antigens, genes and haplotypes in the migrant population of Magadan as a function of length of residence in the region].

作者信息

Pereverzeva V V, Solovenchuk L L

出版信息

Genetika. 1996 Sep;32(9):1270-6.

PMID:9026465
Abstract

Peculiarities of the frequency distribution of antigens, genes, and haplotypes at subloci A, B, and Cw of the HLA system in 1429 Slavic inhabitants of Magadan are presented in dependence on length of residence in extreme conditions. No significant differences were revealed with respect to frequency of genes and antigens in inhabitants with different lengths of residence in northeastern Russian conditions. Analysis of gamete associations shows that the revealed positive or negative associativity in some cases is characteristic for Caucasoids on the whole, but an associativity specific to inhabitants of Magadan was also established. Its character depends on the length of residence in extreme conditions.

摘要

本文呈现了1429名马加丹州斯拉夫居民的人类白细胞抗原(HLA)系统A、B和Cw亚位点上抗原、基因和单倍型的频率分布特点,这些特点取决于他们在极端条件下的居住时长。在俄罗斯东北部不同居住时长的居民中,未发现基因和抗原频率存在显著差异。配子关联分析表明,在某些情况下所揭示的正关联或负关联总体上是高加索人种的特征,但也确定了马加丹州居民特有的一种关联。其特征取决于在极端条件下的居住时长。

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