Nies D H
Institut für Mikrobiologie, Martin-Luther-Universität Halle-Wittenberg, Germany.
Appl Microbiol Biotechnol. 1999 Jun;51(6):730-50. doi: 10.1007/s002530051457.
We are just beginning to understand the metabolism of heavy metals and to use their metabolic functions in biotechnology, although heavy metals comprise the major part of the elements in the periodic table. Because they can form complex compounds, some heavy metal ions are essential trace elements, but, essential or not, most heavy metals are toxic at higher concentrations. This review describes the workings of known metal-resistance systems in microorganisms. After an account of the basic principles of homoeostasis for all heavy-metal ions, the transport of the 17 most important (heavy metal) elements is compared.
尽管重金属构成了元素周期表中元素的主要部分，但我们才刚刚开始了解重金属的代谢，并在生物技术中利用它们的代谢功能。由于一些重金属离子能够形成络合物，它们是必需的微量元素，但是，无论是否必需，大多数重金属在较高浓度时都是有毒的。这篇综述描述了微生物中已知的金属抗性系统的作用机制。在阐述了所有重金属离子的稳态基本原理之后，对17种最重要（重金属）元素的转运进行了比较。
