Bogomolova N S, Oreshkina T D, Bol'shakov L V
Russian Scientific Centre of Surgery, Russian Academy of Medical Sciences, Moscow.
Antibiot Khimioter. 1999;44(6):27-32.
Antibacterial activity and efficacy of cefuroxime (ketocef, Pliva, Zagreb) in the treatment and prophylaxis of surgical infections in a general hospital and particularly in the unit of vessel and aorta surgery, the unit of lung surgery and the unit of microsurgery were estimated. The study included 57 patients (43 males and 14 females) at the age of 21 to 70 years. Cefuroxime was administered intravenously in a dose of 1.5 g followed by its intramuscular administration in a dose of 750 mg with an interval of 8 hours. The results showed that cefuroxime was effective in the treatment (80 per cent) and prophylaxis (93.6 per cent) of the pyo-inflammatory complications and was active against the majority of the surgical infection pathogens.
评估了头孢呋辛（凯福隆，普利瓦公司，萨格勒布）在综合医院，特别是血管和主动脉外科、肺外科和显微外科手术感染治疗和预防中的抗菌活性及疗效。该研究纳入了57例年龄在21至70岁之间的患者（43例男性和14例女性）。头孢呋辛静脉给药剂量为1.5g，随后每8小时肌肉注射750mg。结果表明，头孢呋辛在治疗（80%）和预防（93.6%）脓性炎症并发症方面有效，并且对大多数手术感染病原体具有活性。
