Hugo H, Dornbusch K, Sterner G
Scand J Infect Dis. 1980;12(3):227-30. doi: 10.3109/inf.1980.12.issue-3.11.
Data are presented on the absorption, antibacterial activity, clinical efficacy and side effects of cefuroxime in 33 cases with proven bacterial infection in soft tissues and in patients with septicaemia. The drug was administered mainly intramuscularly (i.m.) but also intravenously (i.v.). Peak serum concentrations 1 h after an injection of 750 mg cefuroxime i.m. were between 16-25 mug/ml. After 8 h the levels were mostly < 4 mug/ml in patients with normal renal function. I.v. injection gave only slightly higher maximum serum level obtained was approximately 40 mug/ml. No accumulation of the drug occurred in patients with normal renal function. Cefuroxime was active against all the gram-positive bacteria isolated from our patients as well as most of the gram-negatives. The clinical effect was satisfactory in 96%. The drug was well tolerated. Side effects were slight and relatively few.
本文给出了头孢呋辛在33例确诊为软组织细菌感染患者和败血症患者中的吸收、抗菌活性、临床疗效及副作用的数据。药物主要通过肌肉注射给药，但也有静脉注射给药。肌肉注射750mg头孢呋辛1小时后血清峰值浓度在16 - 25μg/ml之间。肾功能正常的患者8小时后血药浓度大多<4μg/ml。静脉注射的最高血清水平仅略高，约为40μg/ml。肾功能正常的患者未出现药物蓄积。头孢呋辛对从我们患者中分离出的所有革兰氏阳性菌以及大多数革兰氏阴性菌均有活性。临床有效率为96%。该药物耐受性良好。副作用轻微且相对较少。
