Pataki I, Jászberényi M, Telegdy G
Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Peptides. 1999;20(2):193-7. doi: 10.1016/s0196-9781(98)00173-9.
The effects of atrial natriuretic peptide (ANP-28), brain natriuretic peptide (BNP-32) and C-type natriuretic peptide (CNP-22) on body temperature were investigated in rats. Intracerebroventricular administration of each peptide in doses of 400 or 1000 ng caused a dose-related elevation in colon temperature 30 and 60 min after injection. A 40 ng dose of ANP-28 was also hyperthermic at 60 min. An intramuscular (i.m.) injection of noraminophenazone (a cyclooxygenase inhibitor) abolished the natriuretic peptide-induced hyperthermia. The results show that natriuretic peptides may participate in thermoregulatory processes in the central nervous system, and that their hyperthermic effect may be mediated via a cyclooxygenase-involved pathway.
研究了心房利钠肽（ANP - 28）、脑利钠肽（BNP - 32）和C型利钠肽（CNP - 22）对大鼠体温的影响。以400或1000 ng的剂量脑室内注射每种肽后，在注射后30和60分钟引起结肠温度呈剂量相关的升高。40 ng剂量的ANP - 28在60分钟时也引起体温升高。肌肉注射氨基比林（一种环氧化酶抑制剂）消除了利钠肽诱导的体温升高。结果表明，利钠肽可能参与中枢神经系统的体温调节过程，并且它们的体温升高作用可能通过涉及环氧化酶的途径介导。
