Gasbarrini A, Franceschi F
Internal Medicine Department, Catholic University of Rome, Italy.
Biomed Pharmacother. 1999 Jun;53(5-6):223-6. doi: 10.1016/S0753-3322(99)80092-4.
In the last few years several studies have been performed on the association between H. pylori infection and a miscellany of extragastric disorders which also include autoimmune diseases. In particular, emerging evidence seems to give a potential role for H. pylori in ischaemic heart disease via a cross mimicry between antibodies against heat shock protein 65 which are produced in the consequence of infection, but which are also expressed in atherosclerotic lesions. In cases of healing of Sjogren syndrome and Schonlein-Henoch, purpura have also been reported. A recent study, moreover, showed that eradication of H. pylori infection may be effective in the disappearance of autoimmune thrombocytopenia. Finally, a role for H. pylori has also been postulated in other autoimmune diseases such as membranous nephropathy and some acute immune polyneuropathies. The mechanisms behind these clinical observations still remain unclear. However, if confirmed, these findings could revise the diagnostic and therapeutic approach to diseases previously considered as idiopathics.
在过去几年里，已经开展了多项关于幽门螺杆菌感染与一系列胃外疾病（其中也包括自身免疫性疾病）之间关联的研究。特别是，新出现的证据似乎表明，幽门螺杆菌通过感染后产生的抗热休克蛋白65抗体之间的交叉模拟，在缺血性心脏病中可能发挥潜在作用，而这种抗体也在动脉粥样硬化病变中表达。在干燥综合征和过敏性紫癜治愈的病例中也有相关报道。此外，最近一项研究表明，根除幽门螺杆菌感染可能对自身免疫性血小板减少症的消失有效。最后，幽门螺杆菌在其他自身免疫性疾病（如膜性肾病和一些急性免疫性多发性神经病）中也被假定发挥作用。这些临床观察背后的机制仍不清楚。然而，如果得到证实，这些发现可能会改变先前被认为是特发性疾病的诊断和治疗方法。
