Franceschi F, Roccarina D, Gasbarrini A
Department of Internal Medicine, Catholic University of Rome, Rome, Italy.
Minerva Med. 2006 Feb;97(1):39-45.
Since the discovery of Helicobacter pylory (H. pylori), several studies have been published concerning a hypothetical role of this bacterium in different extragastric diseases, such as ischemic heart disease, idiopathic thrombocytopenic purpura, iron deficiency anemia or other disorders. The majority of those studies may be classified as epidemiological or eradicating trials but there are also case reports or in vitro studies. Idiopathic thromobocytopenic purpura represents the disease showing a stronger link with H. pylori infection. There are also increasing evidences on the role of H. pylori infection in iron deficiency anemia and ischemic heart disease. On the contrary, the association between H. pylori infection and other diseases is still controversial, as is supported in the majority of the cases by case reports, small pilot studies or just in vitro data.
自幽门螺杆菌（H. pylori）被发现以来，已经发表了几项关于这种细菌在不同胃外疾病（如缺血性心脏病、特发性血小板减少性紫癜、缺铁性贫血或其他疾病）中假设作用的研究。这些研究大多数可归类为流行病学或根除试验，但也有病例报告或体外研究。特发性血小板减少性紫癜是与幽门螺杆菌感染联系更为紧密的疾病。关于幽门螺杆菌感染在缺铁性贫血和缺血性心脏病中的作用也有越来越多的证据。相反，幽门螺杆菌感染与其他疾病之间的关联仍存在争议，在大多数情况下，仅有病例报告、小型试点研究或体外数据支持。
