Perri F, Clemente R, Festa V, De Ambrosio C C, Quitadamo M, Fusillo M, Grossi E, Andriulli A
Division of Gastroenterology, Casa Sollievo della Sofferenza Hospital, I.R.C.C.S., San Giovanni Rotondo, Italy.
Ital J Gastroenterol Hepatol. 1999 May;31(4):290-4.
Helicobacter pylori causes gastric inflammation secondary to the mucosal release of cytokines and tumour necrosis factor-alpha.
To investigate whether serum levels of tumor necrosis factor-alpha correlate with Helicobacter pylori infection, CagA antibodies, 13C-urea breath test results, endoscopic, and histological findings.
Endoscopy (with gastric biopsies), 13C-urea breath test, and serological assay of CagA antibodies and tumour necrosis factor-alpha were performed in 172 dyspeptic patients.
A total of 126 patients (73.2%) were infected; of the 126 patients, 84 with CagA antibodies (66.7%) showed a higher prevalence rate of duodenal ulcer (p = 0.03), more severe neutrophil infiltration (p = 0.03) and higher bacterial colonization (p = 0.03) than those without antibodies. CagA+ and CagA- groups differed also in 13C-urea breath test results (p = 0.03). A significant difference in serum tumour necrosis factor-alpha levels was observed between infected and uninfected individuals (p = 0.03) as well as between CagA+ and CagA- patients (p = 0.002).
Helicobacter pylori infection is associated with increased serum levels of tumour necrosis factor-alpha. Subjects who harbour CagA positive strains have more severe mucosal damage, higher bacterial colonization, higher probability of developing duodenal ulcer and higher serum levels of tumour necrosis factor-alpha than those infected with CagA- strains.
幽门螺杆菌通过细胞因子和肿瘤坏死因子-α的黏膜释放导致胃炎症。
研究肿瘤坏死因子-α的血清水平是否与幽门螺杆菌感染、CagA抗体、13C-尿素呼气试验结果、内镜检查及组织学发现相关。
对172例消化不良患者进行了内镜检查（同时取胃活检）、13C-尿素呼气试验以及CagA抗体和肿瘤坏死因子-α的血清学检测。
共有126例患者（73.2%）感染；在这126例患者中，84例有CagA抗体（66.7%），与无抗体者相比，十二指肠溃疡患病率更高（p = 0.03），中性粒细胞浸润更严重（p = 0.03），细菌定植率更高（p = 0.03）。CagA阳性和阴性组在13C-尿素呼气试验结果上也存在差异（p = 0.03）。感染组与未感染组之间（p = 0.03）以及CagA阳性和阴性患者之间（p = 0.002）血清肿瘤坏死因子-α水平存在显著差异。
幽门螺杆菌感染与血清肿瘤坏死因子-α水平升高有关。携带CagA阳性菌株的受试者比感染CagA阴性菌株的受试者有更严重的黏膜损伤、更高的细菌定植率、更高的十二指肠溃疡发生概率以及更高的血清肿瘤坏死因子-α水平。
