Jia Yiguo, Qu Baoge, Wang Zhongdong, Han Xinghai, Ren Guangying
Internal Medicine Department of Gastroenterology Clinical Laboratory Taishan Medical College, Taishan Hospital, Taian, Shandong, P. R. China.
Medicine (Baltimore). 2018 Aug;97(34):e11991. doi: 10.1097/MD.0000000000011991.
This study aimed to explore the effects of active and latent Helicobacter pylori infection coupled with alcohol consumption on cytokine profiles and markers of oxidative balance in men seropositive for H. pylori CagA Ab.The 100 male subjects were divided into groups with active H. pylori infection and H. pylori CagA Ab coupled with chronic alcohol ingestion (group A, n = 38), latent H. pylori infection with H. pylori CagA Ab coupled with chronic alcohol ingestion (group B, n = 30), and latent H. pylori infection with H. pylori CagA Ab without chronic alcohol ingestion (group C, n = 32).No differences in serum levels of CRP, IL-10, ADP, E-selectin, MDA, or SOD were detected between the 3 groups or between any 2 groups (all P > .05). The serum IL-6 and TNF-α concentrations in groups A and B were significantly lower than those in group C (P = .004, P = .005, P = .009, and P = .023). However, there were no differences in serum IL-6 and TNF-α between group A and group B (all P > .05).In conclusion, active or latent H. pylori infection coupled with chronic alcohol ingestion may decrease certain cytokines, that is, IL-6 and TNF-α, in men with H. pylori CagA Ab seropositivity. However, there was no difference in the detected cytokine profile between active and latent H. pylori infection coupled with chronic alcohol ingestion, and no changes were detected in markers of oxidative balance in men with H. pylori CagA Ab.
本研究旨在探讨幽门螺杆菌（Helicobacter pylori，Hp）现症感染和潜伏感染联合饮酒对细胞因子谱以及幽门螺杆菌细胞毒素相关蛋白A（CagA）抗体血清阳性男性氧化平衡标志物的影响。100名男性受试者被分为三组：现症Hp感染联合慢性酒精摄入且幽门螺杆菌CagA抗体阳性（A组，n = 38）；潜伏Hp感染联合慢性酒精摄入且幽门螺杆菌CagA抗体阳性（B组，n = 30）；潜伏Hp感染且幽门螺杆菌CagA抗体阳性但无慢性酒精摄入（C组，n = 32）。三组之间或任意两组之间的血清C反应蛋白（CRP）、白细胞介素-10（IL-10）、二磷酸腺苷（ADP）、E选择素、丙二醛（MDA）或超氧化物歧化酶（SOD）水平均无差异（所有P>0.05）。A组和B组的血清白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）浓度显著低于C组（P = 0.004、P = 0.005、P = 0.009和P = 0.023）。然而，A组和B组之间的血清IL-6和TNF-α无差异（所有P>0.05）。总之，现症或潜伏Hp感染联合慢性酒精摄入可能会降低幽门螺杆菌CagA抗体血清阳性男性的某些细胞因子，即IL-6和TNF-α。然而，现症和潜伏Hp感染联合慢性酒精摄入之间检测到的细胞因子谱没有差异，幽门螺杆菌CagA抗体阳性男性的氧化平衡标志物也没有变化。
