Departments of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.
Health Management Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.
Front Cell Infect Microbiol. 2023 Jun 9;13:1196338. doi: 10.3389/fcimb.2023.1196338. eCollection 2023.
() has increasingly been shown to be related to extragastric diseases. Glycated hemoglobin A1c (HbA1c), an indicator of glycemic control, is closely linked to the event of diabetes. The purpose of this research was to analyze the association between and HbA1c through a cohort study.
The population who underwent multiple physical checkups in the physical examination center of Taizhou Hospital was included. All of them underwent urea breath test, serological examination and physical parameter measurement. Multiple regression was used for analyzing the influencing factors of HbA1c. In addition, the result of HbA1c on infection was studied by restricted cubic spline (RCS) analysis. The triglyceride glucose (TyG) index represents the level of insulin resistance (IR) in the population. The population was classified on the basis of primary and last infection, therefore, the variations of HbA1c and TyG index among totally different teams were investigated.
Multiple regression demonstrated that was an influential factor in HbA1c. RCS analysis showed a nonlinear relationship between HbA1c and infection. When HbA1c>5.7%, the chance of infection was considerably enlarged. Additionally, long-term infection increased HbA1c levels, while HbA1c levels decreased after eradication. Similarly, long-term infection also increased the TyG index.
Prediabetes increases the danger of infection, long-term infection increases HbA1c and IR levels, and wipeout of could have a positive impact for glycemic control in the population.
幽门螺杆菌（）与多种胃外疾病的发生密切相关。糖化血红蛋白（HbA1c）是血糖控制的指标，与糖尿病的发生密切相关。本研究旨在通过队列研究分析与 HbA1c 之间的关系。
纳入在台州医院体检中心接受多次体检的人群。所有人群均进行尿素呼气试验、血清学检查和身体参数测量。采用多元回归分析 HbA1c 的影响因素。此外，通过受限立方样条（RCS）分析研究 HbA1c 对感染的影响。三酰甘油葡萄糖（TyG）指数反映人群的胰岛素抵抗（IR）水平。根据初次和末次感染，将人群进行分类，因此，研究了不同组别之间 HbA1c 和 TyG 指数的变化。
多元回归显示是 HbA1c 的影响因素。RCS 分析显示 HbA1c 与感染之间存在非线性关系。当 HbA1c>5.7%时，感染的几率明显增加。此外，长期感染会增加 HbA1c 水平，而根除后 HbA1c 水平会降低。同样，长期感染也会增加 TyG 指数。
糖尿病前期增加了感染的危险，长期感染会增加 HbA1c 和 IR 水平，而清除可对人群的血糖控制产生积极影响。
