Lund-Johansen F, Olweus J
DNAX Research Institute for Cellular and Molecular Immunology, Palo Alto, CA 94306, USA.
Tidsskr Nor Laegeforen. 1999 Jun 30;119(17):2510-4.
Why are immune responses primarily directed towards infectious agents, and how can the immune system be manipulated to attack for instance malignant cells? The role of the dendritic cells in the immune system may provide the answers. We present a review of a field in which results from basic science are rapidly applied in clinical trials. We searched the Medline database using the terms dendritic cells combined with ontogeny, subpopulations, vaccine or review. Results from our own experimental work are also described. The cited studies show that dendritic cells take up material from their surroundings and migrate to lymphoid tissue where the material is presented to T-cells. Dendritic cells have the ability to selectively direct immune responses towards potentially harmful agents such as bacteria and viruses. Clinical trials show that vaccines based on the use of dendritic cells induce tumor-specific immunity and clinical remission. Experiments conducted by the authors and others indicate the existence of subpopulations of dendritic cells with specialized functions. Dendritic cells play a central role in the initiation of immune responses and may be used to manipulate the immune system. Their use in the treatment of diseases such as cancer is highly promising.
为什么免疫反应主要针对感染因子，以及如何操控免疫系统来攻击例如恶性细胞呢？树突状细胞在免疫系统中的作用或许能提供答案。我们对一个基础科学成果迅速应用于临床试验的领域进行综述。我们使用“树突状细胞”结合个体发生、亚群、疫苗或综述等术语在医学文献数据库中进行检索。同时也描述了我们自己实验工作的结果。引用的研究表明，树突状细胞摄取周围环境中的物质并迁移至淋巴组织，在那里将这些物质呈递给T细胞。树突状细胞有能力选择性地引导针对潜在有害因子如细菌和病毒的免疫反应。临床试验表明，基于使用树突状细胞的疫苗可诱导肿瘤特异性免疫和临床缓解。作者及其他人进行的实验表明存在具有特定功能的树突状细胞亚群。树突状细胞在免疫反应的启动中起核心作用，并且可用于操控免疫系统。它们在诸如癌症等疾病治疗中的应用前景广阔。
