通过CD95L cDNA转染的“杀伤性”树突状细胞诱导抗原特异性免疫抑制。
Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells.
作者信息
Matsue H, Matsue K, Walters M, Okumura K, Yagita H, Takashima A
机构信息
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235-9069, USA.
出版信息
Nat Med. 1999 Aug;5(8):930-7. doi: 10.1038/11375.
Dendritic cells (DCs) are special subsets of antigen-presenting cells characterized by their highly potent capacity to activate immunologically naive T cells. Here we report that DCs that are transfected with CD95 ligand (CD95L) cDNA, called 'killer' DCs, deliver death signals, instead of activation signals, to T cells after antigen-specific interaction. Injection of antigen-pulsed killer DCs into mice before sensitization induced antigen-specific immunosuppression. When administered after sensitization, killer DCs suppressed immune responses almost completely after subsequent challenge. Thus, killer DCs represent an entirely new immunomodulatory protocol, which may become directly applicable in preventing and even treating T cell-mediated inflammatory diseases.
树突状细胞（DCs）是抗原呈递细胞的特殊亚群，其特征在于具有高度有效的激活免疫未成熟T细胞的能力。我们在此报告，用CD95配体（CD95L）cDNA转染的DCs，即所谓的“杀伤性”DCs，在抗原特异性相互作用后，向T细胞传递死亡信号而非激活信号。在致敏前将抗原脉冲化的杀伤性DCs注射到小鼠体内可诱导抗原特异性免疫抑制。致敏后给予杀伤性DCs，在随后的攻击后杀伤性DCs几乎完全抑制免疫反应。因此，杀伤性DCs代表了一种全新的免疫调节方案，可能直接适用于预防甚至治疗T细胞介导的炎症性疾病。
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