Crippa G E, Peres-Polon V L, Kuboyama R H, Corrêa F M
Department of Pharmacology, School of Medicine of Ribeirão Preto, São Paulo, Brazil.
Cereb Cortex. 1999 Jun;9(4):362-5. doi: 10.1093/cercor/9.4.362.
Injection of acetylcholine (ACh) (2.5-60 nmol) into the anterior cingulate cortex caused dose-dependent hypotensive responses (Emax = -25.3 mmHg) and no change in the heart rate. The hypotensive response to 30 nmol of ACh was blocked by local pretreatment with atropine (3 nmol) or 4-DAMP (6.7 nmol), a non-tropine muscarinic antagonist. When the same dose of atropine was injected i.v., no changes were observed in the hypotensive response to intracortical ACh. This observation rules out the possible leakage of ACh into the peripheral circulation and favors the idea of a cortical site of action. The injection of the same dose of ACh into the corpus callosum or the occipital cortex did not cause changes in the cardiovascular system. The present results confirm earlier evidence that the cingulate cortex is involved in the control of the autonomic system and indicate that cholinergic muscarinic receptors in the cingulate cortex mediate a hypotensive response without a change in heart rate.
向扣带回皮层注射乙酰胆碱（ACh）（2.5 - 60纳摩尔）会引起剂量依赖性的降压反应（最大效应Emax = -25.3毫米汞柱），且心率无变化。对30纳摩尔ACh的降压反应可被局部预先用阿托品（3纳摩尔）或4 - DAMP（6.7纳摩尔，一种非托品类毒蕈碱拮抗剂）预处理所阻断。当静脉注射相同剂量的阿托品时，对皮层内ACh的降压反应未观察到变化。这一观察结果排除了ACh可能漏入外周循环的可能性，并支持了作用位点在皮层的观点。向胼胝体或枕叶皮层注射相同剂量的ACh未引起心血管系统的变化。目前的结果证实了早期的证据，即扣带回皮层参与自主神经系统的控制，并表明扣带回皮层中的胆碱能毒蕈碱受体介导了降压反应而心率无变化。
