Hama S, Arita K, Tominaga A, Yoshikawa M, Eguchi K, Sumida M, Inai K, Nishisaka T, Kurisu K
Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
Endocr J. 1999 Feb;46(1):187-92. doi: 10.1507/endocrj.46.187.
We describe a 48-year-old female with acute onset of central diabetes insipidus followed by mild anterior pituitary dysfunction. Magnetic resonance imaging (MRI) revealed enlargement of the hypophysis-infundibulum accompanied by a cystic component. She underwent a transsphenoidal exploration of the sella turcica. Histological examination showed foreign body type xanthogranulomatous inflammation in the neurohypophysis which might have been caused by rupture of a Rathke's cleft cyst. The MRI abnormalities and anterior pituitary dysfunction improved after a short course of corticosteroid administration, but the diabetes insipidus persisted. The histological findings in this case indicated the site of RCC rupture and the direction of the progression of RCC induced neurohypophysitis and adenohypophysitis.
我们描述了一名48岁女性，其急性起病，先是中枢性尿崩症，随后出现轻度垂体前叶功能障碍。磁共振成像（MRI）显示垂体-漏斗部增大，伴有囊性成分。她接受了经蝶窦垂体探查术。组织学检查显示神经垂体有异物型黄色肉芽肿性炎症，这可能是由拉克氏裂囊肿破裂所致。短期给予皮质类固醇治疗后，MRI异常及垂体前叶功能障碍有所改善，但尿崩症仍持续存在。该病例的组织学发现提示了拉克氏裂囊肿破裂的部位以及拉克氏裂囊肿诱发神经垂体炎和腺垂体炎的进展方向。
