Ishiko O, Nishimura S, Yasui T, Sumi T, Hirai K, Honda K, Ogita S
Department of Obstetrics and Gynecology, Osaka City University Medical School.
Jpn J Cancer Res. 1999 Jun;90(6):655-9. doi: 10.1111/j.1349-7006.1999.tb00797.x.
Changes in total body fat and the metabolic and morphologic characteristics of adipose tissue were sequentially investigated in individual rabbits implanted with VX2 tumors to elucidate the pathology of the fat reduction in animals with malignant tumors as compared with that of diet-restricted rabbits. Lipogenesis in normal, VX2-implanted, and diet-restricted rabbit groups on day 40 after the start of the experiments was 19.1 +/- 2.9, 13.3 +/- 3.5, and 41.7 +/- 6.0 x 10(5) cpm/g/h, respectively, and glycerol liberation by their adipose tissue was 199 +/- 21, 528 +/- 94, and 301 +/- 45 nmol/g/h, respectively. In addition, apoptotic cells were noted in the adipose tissue of VX2-implanted rabbits on days 20-30 after implantation, but not in diet-restricted rabbits. The results showed clear differences between the total body fat reduction profiles of VX2-implanted rabbits and diet-restricted rabbits, suggesting a characteristic lipid metabolism with enhanced lipolysis and diminished lipogenesis in VX2-implanted rabbits. The results strongly suggest that adipocyte apoptosis might be involved in these phenomena.
为了阐明与饮食限制的兔子相比，植入VX2肿瘤的兔子体内脂肪减少的病理情况，我们对植入VX2肿瘤的兔子个体进行了全身脂肪变化以及脂肪组织代谢和形态特征的系列研究。实验开始后第40天，正常、植入VX2肿瘤和饮食限制的兔子组的脂肪生成分别为19.1±2.9、13.3±3.5和41.7±6.0×10(5) cpm/g/h，其脂肪组织甘油释放量分别为199±21、528±94和301±45 nmol/g/h。此外，植入VX2肿瘤的兔子在植入后20 - 30天，其脂肪组织中出现凋亡细胞，而饮食限制的兔子则未出现。结果表明，植入VX2肿瘤的兔子和饮食限制的兔子在全身脂肪减少情况方面存在明显差异，这表明植入VX2肿瘤的兔子具有脂肪代谢特征，即脂肪分解增强而脂肪生成减少。结果强烈提示，脂肪细胞凋亡可能与这些现象有关。
