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荷瘤兔循环血浆灌注后成肌细胞增殖增加。

Increased proliferation of myoblasts after cyclic plasma perfusion of tumor-bearing rabbits.

作者信息

Nakata S, Ishiko O, Honda K, Hirai K, Deguchi M, Ogita S

机构信息

Department of Obstetrics and Gynecology, Osaka City University Medical School.

出版信息

Jpn J Cancer Res. 1998 May;89(5):578-82. doi: 10.1111/j.1349-7006.1998.tb03300.x.

DOI:10.1111/j.1349-7006.1998.tb03300.x
PMID:9685863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5921846/
Abstract

Rabbits implanted with VX2 carcinoma and treated by cyclic plasma perfusion showed lower weight loss and longer survival than untreated rabbits. The urinary 3-methylhistidine/creatine ratio was less elevated in the treated rabbits than in the untreated rabbits. Myoblasts from untreated rabbits with VX2 carcinoma showed lower proliferation than those from normal rabbits, while those from rabbits treated by cyclic plasma perfusion showed intermediate proliferation. Furthermore, the DNA synthesis rate of myoblasts from treated rabbits was much better maintained than in the case of untreated rabbits.

摘要

植入VX2癌并接受循环血浆灌注治疗的兔子，相较于未治疗的兔子，体重减轻更少，存活时间更长。治疗组兔子尿中3-甲基组氨酸/肌酸比值的升高程度低于未治疗组兔子。患有VX2癌的未治疗兔子的成肌细胞增殖能力低于正常兔子的成肌细胞，而接受循环血浆灌注治疗的兔子的成肌细胞增殖能力处于中间水平。此外，治疗组兔子成肌细胞的DNA合成速率比未治疗组兔子的更好地得以维持。

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