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[儿童哮吼]

[Childhood croup].

作者信息

Lebecque P

机构信息

Clinique Saint-Luc, université de Louvain, Bruxelles, Belgique.

出版信息

Arch Pediatr. 1999 Jul;6(7):768-74. doi: 10.1016/S0929-693X(99)80362-5.

DOI:10.1016/S0929-693X(99)80362-5
PMID:10429820
Abstract

Hoarseness, whooping cough and stridor are elements of a syndrome of upper airway obstruction. In childhood, acute laryngotracheobronchitis is by far the commonest cause of this syndrome. Yet, the differential diagnosis includes a number of rare and severe entities. In many cases, the traditional distinction between viral and spasmodic types is not possible. The value of humidifying therapy has not been established. In severe cases, nebulized adrenaline is of benefit but should be reserved for hospital. The effect lasts only two hours and at times a rebound effect is observed. It is now realized that some patients treated with adrenaline can safely be discharged after a two to three hours observation. There is a large body of evidence that all children arriving at the emergency department with croup should receive steroids without delay. This policy results in a much better outcome, with important reduction in hospitalizations, intensive care unit admissions and incubations. Oral dexamethasone is the drug of choice: it is as effective, easier to administer and cheaper than nebulised budesonide. In most studies, dexamethasone has been used at a dose of 0.6 mg/kg but there is some evidence that 0.15 mg/kg may be just as effective.

摘要

声音嘶哑、百日咳和喘鸣是上呼吸道梗阻综合征的症状表现。在儿童时期,急性喉气管支气管炎是该综合征最常见的病因。然而,鉴别诊断还包括一些罕见且严重的疾病。在很多情况下,无法对病毒型和痉挛型进行传统区分。湿化疗法的价值尚未确定。在严重病例中,雾化吸入肾上腺素有益,但应留院使用。其效果仅持续两小时,有时会出现反跳效应。现在认识到,一些接受肾上腺素治疗的患者在观察两到三小时后可安全出院。有大量证据表明,所有因喉炎到急诊科就诊的儿童都应立即接受类固醇治疗。这一政策会带来更好的结果,可显著减少住院、重症监护病房收治和插管情况。口服地塞米松是首选药物:它与雾化吸入布地奈德效果相同,给药更方便且价格更低。在大多数研究中,地塞米松的使用剂量为0.6毫克/千克,但有证据表明0.15毫克/千克可能同样有效。

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