Dalaker M, Jacobsen T, Lysvand H, Iversen O J
Department of Dermatology, University Hospital, NTNU, Trondheim, Norway.
Acta Derm Venereol. 1999 Jul;79(4):281-4. doi: 10.1080/000155599750010661.
The psoriasis-associated antigen, pso p27, can be isolated from psoriasis scale and is present in complement-activating immune complexes in psoriatic scale, and in serum from patients with psoriasis. The antigen is produced by tryptase-positive cells in the skin lesions and is shown to be a major antigen in the immune reactions in psoriasis. The synthesis of this particular antigen is reduced with the remission of inflammation in the skin lesions. In this study we followed 3 patients with severe plaque psoriasis during treatment with cyclosporin A. In all patients we observed a decrease in the expression of the antigen pso p27 during the therapy. The effectiveness of the therapy varied among the patients, but there was a clear correlation between disease activity and expression of the antigen pso p27 as demonstrated by immunofluorescence in biopsies from selected skin lesions. This observation strengthens our hypothesis that the pso p27 antigen plays an important role in the inflammation in psoriasis.
银屑病相关抗原pso p27可从银屑病鳞屑中分离出来，存在于银屑病鳞屑以及银屑病患者血清中的补体激活免疫复合物中。该抗原由皮肤病变中的类胰蛋白酶阳性细胞产生，并且被证明是银屑病免疫反应中的主要抗原。随着皮肤病变炎症的缓解，这种特定抗原的合成会减少。在本研究中，我们对3例重度斑块状银屑病患者使用环孢素A进行治疗。在所有患者中，我们观察到治疗期间抗原pso p27的表达下降。患者之间治疗效果有所不同，但通过对选定皮肤病变活检进行免疫荧光检测表明，疾病活动与抗原pso p27的表达之间存在明显相关性。这一观察结果强化了我们的假设，即pso p27抗原在银屑病炎症中起重要作用。
