Department of Dermatology, Guang An'men Hospital, China Academy of Chinese Medical Sciences, No 5 Beixiange Street, Xuan Wu District, Beijing, China.
J Ethnopharmacol. 2010 Jan 8;127(1):171-4. doi: 10.1016/j.jep.2009.09.030. Epub 2009 Sep 23.
Pso p27 is shown to be an autoantigen in psoriasis and the objective of the present study was to investigate whether Traditional Chinese Medicine (TCM) would influence the expression of Pso p27.
Skin biopsies obtained from psoriatic patients before and after treatment with TCM were analyzed for the presence of Pso p27 antigen by indirect immunofluorescence using murine monoclonal antibodies against Pso p27.
A significant reduction in the amount of Pso p27 in the psoriatic skin was obtained after treatment with TCM for 3 months.
The presence of Pso p27 in psoriatic skin is reduced when psoriatic patients are treated with TCM.
Pso p27 被证明是银屑病的自身抗原，本研究的目的是探讨中药（TCM）是否会影响 Pso p27 的表达。
使用针对 Pso p27 的鼠单克隆抗体通过间接免疫荧光法分析来自接受 TCM 治疗前后的银屑病患者的皮肤活检，以检测 Pso p27 抗原的存在。
接受 TCM 治疗 3 个月后，银屑病皮肤中 Pso p27 的量明显减少。
当银屑病患者接受 TCM 治疗时，银屑病皮肤中存在的 Pso p27 减少。
