Locatelli A, Roncaglia N, Arreghini A, Bellini P, Vergani P, Ghidini A
Department of Obstetrics and Gynecology, Istituto Scienze Biomediche San Gerardo, Monza, Italy.
Br J Obstet Gynaecol. 1999 May;106(5):498-500. doi: 10.1111/j.1471-0528.1999.tb08305.x.
To investigate a possible relationship between hepatitis C virus infection and cholestasis of pregnancy, we identified all cases of cholestasis of pregnancy (145/16,271) and hepatitis C virus infection (63/16,271) between January 1992 and December 1997. Serologic screening was performed universally. The rate of cholestasis of pregnancy was greater in women whose hepatitis C virus antibodies were positive rather than negative [15.9% (10/63) vs 0.8% (135/16,208), P < 0.001]. Among women with cholestasis of pregnancy, mean (standard deviation) gestational age at onset of symptoms and at delivery was significantly lower among women whose hepatitis C virus antibodies were positive compared with negative women: 28.9 (3.2) vs 34.3 (3.5) weeks, P < 0.001 and 36.3 (0.9) vs 37.0 (1.6) weeks, P = 0.03, respectively. These findings suggest that early occurrence of cholestasis of pregnancy may be an indication for serologic testing for hepatitis C virus.
为了研究丙型肝炎病毒感染与妊娠期胆汁淤积症之间可能存在的关系，我们确定了1992年1月至1997年12月期间所有妊娠期胆汁淤积症病例（145/16271）和丙型肝炎病毒感染病例（63/16271）。对所有病例均进行了血清学筛查。丙型肝炎病毒抗体呈阳性的女性发生妊娠期胆汁淤积症的比例高于抗体呈阴性的女性[15.9%（10/63）对0.8%（135/16208），P<0.001]。在妊娠期胆汁淤积症女性中，丙型肝炎病毒抗体呈阳性的女性出现症状时和分娩时的平均（标准差）孕周显著低于抗体呈阴性的女性：分别为28.9（3.2）周对34.3（3.5）周，P<0.001；以及36.3（0.9）周对37.0（1.6）周，P=0.03。这些发现表明，妊娠期胆汁淤积症的早期发生可能是进行丙型肝炎病毒血清学检测的一个指征。
