Birchall Courtney, Prentice Danielle, Pauli Jaimey
Obstetrics and Gynecology Penn State Health Milton S. Hershey Medical Center, USA.
Maternal Fetal Medicine Penn State Health Milton S. Hershey Medical Center, USA.
Case Rep Womens Health. 2020 Jan 30;26:e00178. doi: 10.1016/j.crwh.2020.e00178. eCollection 2020 Apr.
Severe intrahepatic cholestasis of pregnancy (ICP), defined as a serum bile acid (SBA) level > 100 μmol/l, remains poorly understood in its mechanism and implications.
A patient with a missed diagnosis of mild ICP went on to develop clinical jaundice and liver function abnormalities in the setting of newly diagnosed hepatitis C and severe ICP on repeat SBA testing.
This case highlights and adds to the growing body of evidence supporting the need for universal screening for hepatitis C in ICP patients and the potential role for repeat SBA testing, which would be a notable change from the traditional care of these individuals.
妊娠合并严重肝内胆汁淤积症（ICP）定义为血清胆汁酸（SBA）水平>100μmol/l，其发病机制及影响仍知之甚少。
一名轻度ICP漏诊患者，在新诊断为丙型肝炎且重复SBA检测显示为严重ICP的情况下，继而出现临床黄疸和肝功能异常。
该病例突出并补充了越来越多的证据，支持对ICP患者进行丙型肝炎普遍筛查的必要性以及重复SBA检测的潜在作用，这将是这些患者传统治疗方法的一个显著改变。
