Nakama H, Kayano T, Katsuura T, Kamigaito T, Shimada S, Nishikawa N, Yoshii S, Kamijo N
Department of Public Health, Shinshu University School of Medicine, Matsumoto, Japan.
Hepatogastroenterology. 1999 May-Jun;46(27):1730-2.
BACKGROUND/AIMS: To clarify the association between a sign of rectal bleeding and colorectal cancer, and to reveal the relationship of rectal bleeding to the results of an immunochemical fecal occult blood test.
In a population-based cross sectional study, 30,138 subjects who received immunochemical fecal occult blood screening with a 2-day method were divided into two groups, according to the results of a questionnaire on a sign of rectal bleeding, and the positivity rate of an immunochemical occult blood test as well as the predictive value for colorectal cancer were compared in the two groups.
The fecal occult blood test was positive in 8.8% of subjects with rectal bleeding and in 6.0% of subjects without rectal bleeding, and the predictive value was 6.4% and 3.3% in subjects with and without rectal bleeding, respectively, showing a significant difference in the positivity rate (p<0.001) as well as the predictive value (p<0.05) between these two groups.
These findings indicate that there are positive relations between the subjects with rectal bleeding presentation and colorectal cancer, and a sign of rectal bleeding and the results of an immunochemical fecal occult blood test.
背景/目的：阐明直肠出血体征与结直肠癌之间的关联，并揭示直肠出血与免疫化学粪便潜血试验结果的关系。
在一项基于人群的横断面研究中，30138名采用两日法进行免疫化学粪便潜血筛查的受试者，根据直肠出血体征问卷调查结果分为两组，比较两组免疫化学潜血试验的阳性率及对结直肠癌的预测价值。
直肠出血受试者中粪便潜血试验阳性率为8.8%，无直肠出血受试者中为6.0%，有直肠出血和无直肠出血受试者的预测价值分别为6.4%和3.3%，两组在阳性率（p<0.001）及预测价值（p<0.05）方面均存在显著差异。
这些发现表明，有直肠出血表现的受试者与结直肠癌之间、直肠出血体征与免疫化学粪便潜血试验结果之间存在正相关关系。
