用于结直肠癌筛查的免疫粪便潜血检测的准确性。
Accuracy of immunological fecal occult blood testing for colorectal cancer screening.
作者信息
Nakama H, Kamijo N
机构信息
Department of Public Health, Shinshu University School of Medicine, Nagano, Japan.
出版信息
Prev Med. 1994 May;23(3):309-13. doi: 10.1006/pmed.1994.1043.
BACKGROUND
The present study was carried out to assess the accuracy of immunological fecal occult blood testing as a means for colorectal cancer screening.
METHODS
Two hundred patients with colorectal cancer and 100 healthy controls served as subjects of the study. A total of 300 subjects were tested by immunological and chemical fecal occult blood tests. As a further test of diagnostic accuracy, mass screening for colorectal cancer using immunological fecal occult blood testing was conducted on 3,365 residents within the Nagano prefecture, and all of the subjects were followed for 1 year through verification from cancer registration of colorectal cancer patients.
RESULTS
Sensitivity and specificity of immunological fecal occult blood testing were 67 and 96%, respectively, values significantly higher than those obtained by chemical fecal occult blood testing. Also, sensitivity and specificity in mass screening were 91 and 96%, respectively, indicating an accuracy higher than that achieved by chemical occult testing.
CONCLUSION
These findings suggest that immunological fecal occult blood testing is a useful strategy for colorectal cancer screening.
背景
本研究旨在评估免疫法粪便潜血检测作为结直肠癌筛查手段的准确性。
方法
200例结直肠癌患者和100例健康对照者作为研究对象。300名受试者接受了免疫法和化学法粪便潜血检测。作为诊断准确性的进一步检测，对长野县内3365名居民进行了免疫法粪便潜血检测的结直肠癌大规模筛查，并通过结直肠癌患者癌症登记验证对所有受试者进行了1年的随访。
结果
免疫法粪便潜血检测的敏感性和特异性分别为67%和96%，显著高于化学法粪便潜血检测。此外，大规模筛查中的敏感性和特异性分别为91%和96%，表明其准确性高于化学潜血检测。
结论
这些发现表明免疫法粪便潜血检测是一种有用的结直肠癌筛查策略。
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