Schmier J, Elixhauser A, Halpern M T
MEDTAP International, Bethesda, Maryland 20814, USA.
Hepatogastroenterology. 1999 May-Jun;46(27):1998-2004.
This review addresses the state of the literature on health-related quality of life (HRQL) assessment among patients with cancers of the pancreas and stomach. We first briefly review the epidemiology of these cancers. We examine the concept of HRQL and the degree to which it has been measured among these patient groups. The impact of gastric and pancreatic cancers on HRQL is described, including the domains which these conditions are most likely to impact. The effect of different treatments on HRQL is considered, including surgical procedures, pharmacological and non-pharmacological therapies, and procedures for symptom palliation. Based on our findings on the limited quantity and quality of the body of literature, we make suggestions for further research in the area. Results suggest three areas in which HRQL can play an important role in the study of gastric and pancreatic cancer. First, future investigations should consider both survival and HRQL in comparing surgical procedures. Second, studies of chemotherapy should include HRQL evaluation, with careful attention to conducting assessments at times appropriate to capture the effects of chemotherapy. Third, studies of the impact of palliative care should include assessments of HRQL.
本综述阐述了有关胰腺癌和胃癌患者健康相关生活质量（HRQL）评估的文献现状。我们首先简要回顾这些癌症的流行病学情况。我们审视HRQL的概念以及在这些患者群体中对其进行测量的程度。描述了胃癌和胰腺癌对HRQL的影响，包括这些病症最有可能影响的领域。考虑了不同治疗方法对HRQL的作用，包括外科手术、药物和非药物疗法以及症状缓解程序。基于我们对文献数量有限且质量欠佳的研究结果，我们对该领域的进一步研究提出建议。结果表明HRQL在胃癌和胰腺癌研究中可在三个方面发挥重要作用。首先，未来的研究在比较外科手术时应同时考虑生存率和HRQL。其次，化疗研究应包括HRQL评估，并谨慎留意在适合捕捉化疗效果的时间进行评估。第三，姑息治疗影响的研究应包括HRQL评估。
