脂蛋白(a)：谜题与见解

Lipoprotein(a): intrigues and insights.

作者信息

Hobbs H H, White A L

机构信息

Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas 75235, USA.

出版信息

Curr Opin Lipidol. 1999 Jun;10(3):225-36. doi: 10.1097/00041433-199906000-00005.

DOI:10.1097/00041433-199906000-00005

PMID:10431659

Abstract

Lipoprotein(a) is an atherogenic, cholesterol ester-rich lipoprotein of unknown physiological function. The unusual species distribution of lipoprotein(a) and the extreme polymorphic nature of its distinguishing apolipoprotein component, apolipoprotein(a), have provided unique challenges for the investigation of its biochemistry, genetics, metabolism and atherogenicity. Some fundamental questions regarding this enigmatic lipoprotein have escaped elucidation, as will be highlighted in this review.

摘要

脂蛋白(a)是一种具有致动脉粥样硬化作用、富含胆固醇酯的脂蛋白，其生理功能尚不清楚。脂蛋白(a)不同寻常的物种分布及其独特的载脂蛋白成分——载脂蛋白(a)的极端多态性，为研究其生物化学、遗传学、代谢及致动脉粥样硬化性带来了独特的挑战。关于这种神秘脂蛋白的一些基本问题仍未得到阐明，本综述将着重强调这一点。