Krause T, Turner G A
Department of Clinical Biochemistry, The Medical School, Newcastle upon Tyne, UK.
Clin Exp Metastasis. 1999 May;17(3):183-92. doi: 10.1023/a:1006626500852.
The selectins are a family of intercellular adhesion molecules that mediate the attachment of leukocytes to the endothelial lining of blood vessels. Another biological process that may involve selectins is the adhesion of circulating tumour cells to endothelium in cancer metastasis. This review discusses the evidence for the involvement of E-, P- and L-selectin in the metastasis of different tumour types. It is concluded that, with certain reservations and qualifications, selectins can play a role in metastasis. For example, the evidence for the involvement of E-selectin in breast and colon cancer metastasis is very strong. For the other selectins and tumour types the evidence is less convincing and further investigations are required to clarify the situation. Certainly, selectins are not the only mechanism available for tumours to metastasise. In the future, measurement of selectins could be useful prognostically and manipulation of their levels could lead to new cancer therapies.
选择素是一类细胞间黏附分子家族，介导白细胞与血管内皮的附着。另一个可能涉及选择素的生物学过程是循环肿瘤细胞在癌症转移过程中与内皮的黏附。本综述讨论了E-选择素、P-选择素和L-选择素参与不同肿瘤类型转移的证据。得出的结论是，在有一定保留和限定条件下，选择素可在转移中发挥作用。例如，E-选择素参与乳腺癌和结肠癌转移的证据非常确凿。对于其他选择素和肿瘤类型，证据则不那么令人信服，需要进一步研究以阐明情况。当然，选择素并非肿瘤转移的唯一机制。未来，选择素的检测在预后方面可能有用，对其水平的调控可能会带来新的癌症治疗方法。
