Nooijen P T, Westphal J R, Eggermont A M, Schalkwijk C, Max R, de Waal R M, Ruiter D J
Department of Pathology, University Hospital Nijmegen, The Netherlands.
Am J Pathol. 1998 Mar;152(3):679-82.
Some malignant tumors induce a cellular immune response that results in the formation of an inflammatory infiltrate and subsequent tumor regression. The infiltrating leukocytes extravasate from the bloodstream after binding to adhesion receptors on the surface of the endothelium. One of these receptors is the P-selectin molecule (CD62P) that is constitutively present on normal capillaries. We observed that P-selectin expression is absent from the microvasculature in advanced primary melanoma and in melanoma metastasis in contrast to benign melanocytic lesions where P-selectin expression was identical to that in normal skin. We suggest that one of the mechanisms by which advanced melanoma lesions evade inflammatory regression operates via a decrease of endothelial P-selectin expression.
一些恶性肿瘤会引发细胞免疫反应，导致炎性浸润的形成以及随后的肿瘤消退。浸润的白细胞在与内皮细胞表面的黏附受体结合后从血流中渗出。其中一种受体是P-选择素分子（CD62P），它在正常毛细血管中组成性存在。我们观察到，与良性黑素细胞病变中P-选择素表达与正常皮肤相同相比，晚期原发性黑色素瘤和黑色素瘤转移灶的微血管中不存在P-选择素表达。我们认为，晚期黑色素瘤病变逃避炎性消退的机制之一是通过降低内皮细胞P-选择素表达来实现的。
