Borsig Lubor
Institute of Physiology, University of Zürich, CH-8057 Zürich, Switzerland.
News Physiol Sci. 2004 Feb;19:16-21. doi: 10.1152/nips.01450.2003.
Selectins are cell adhesion molecules mediating attachment of leukocytes to activated endothelium as well as the adhesion reaction of tumors during malignancy. Heparin, which is known to attenuate metastasis, is a potent blocker of selectins. Here, the role of selectins in metastasis and the potential of heparin to modulate malignancy are discussed.
选择素是一类细胞黏附分子，介导白细胞与活化内皮细胞的黏附以及肿瘤在恶性过程中的黏附反应。已知可减弱转移的肝素是选择素的强效阻断剂。本文讨论了选择素在转移中的作用以及肝素调节恶性肿瘤的潜力。
