18F-氟代脱氧葡萄糖正电子发射断层扫描在软骨肉瘤鉴别诊断及分级中的应用

FDG-PET in differential diagnosis and grading of chondrosarcomas.

作者信息

Aoki J, Watanabe H, Shinozaki T, Tokunaga M, Inoue T, Endo K

机构信息

Department of Diagnostic Radiology, Gunma University School of Medicine, Maebashi, Japan.

出版信息

J Comput Assist Tomogr. 1999 Jul-Aug;23(4):603-8. doi: 10.1097/00004728-199907000-00022.

DOI:10.1097/00004728-199907000-00022

PMID:10433294

Abstract

PURPOSE

The purpose of this work was to investigate the usefulness of PET with [18F]2-deoxy-2-fluoro-D-glucose (FDG) in the differential diagnosis and grading of chondrosarcomas.

METHOD

Four enchondromas, one osteochondroma, and six chondrosarcomas were prospectively studied by FDG-PET. The significance of the standardized uptake value (SUV) was evaluated in comparison with clinical, radiological, and histopathological findings of the tumors.

RESULTS

The SUV ranged from 0.7 to 1.3 (mean 0.96+/-0.22) in benign cartilage tumors and from 1.3 to 3.3 (2.23+/-0.80) in chondrosarcomas. This SUV difference between benign and malignant tumors was statistically significant (p = 0.011) in contrast to considerable overlap of clinical and radiological findings. Among chondrosarcomas, the SUV of one Grade I tumor was 1.3; those of four Grade II tumors were 1.3, 1.9, 2.5, and 3.1; and that of one Grade III tumor was 3.3.

CONCLUSION

Our preliminary study showed that FDG-PET could be an objective and quantitative adjunct in the differential diagnosis and grading of chondrosarcomas.

摘要

目的

本研究旨在探讨[18F]2-脱氧-2-氟-D-葡萄糖（FDG）PET在软骨肉瘤鉴别诊断及分级中的应用价值。

方法

对4例内生软骨瘤、1例骨软骨瘤及6例软骨肉瘤进行前瞻性FDG-PET研究。将标准化摄取值（SUV）与肿瘤的临床、放射学及组织病理学表现进行比较，评估其意义。

结果

良性软骨肿瘤的SUV范围为0.7至1.3（平均0.96±0.22），软骨肉瘤的SUV范围为1.3至3.3（2.23±0.80）。与临床和放射学表现存在相当程度的重叠不同，良性与恶性肿瘤之间的SUV差异具有统计学意义（p = 0.011）。在软骨肉瘤中，1例I级肿瘤的SUV为1.3；4例II级肿瘤的SUV分别为1.3、1.9、2.5和3.1；1例III级肿瘤的SUV为3.3。