衰老悖论：衰老的自由基理论。

The aging paradox: free radical theory of aging.

作者信息

Ashok B T, Ali R

机构信息

Department of Biochemistry, J.N. Medical College, Aligarh Muslim University, UP, India.

出版信息

Exp Gerontol. 1999 Jun;34(3):293-303. doi: 10.1016/s0531-5565(99)00005-4.

DOI:10.1016/s0531-5565(99)00005-4

PMID:10433385

Abstract

There are more than 300 theories to explain the aging phenomenon. Many of them originate from the study of changes that accumulate with time. Among all the theories, the free radical theory of aging, postulated first by Harman, is the most popular and widely tested, and is based on the chemical nature and ubiquitous presence of free radicals. This review aims to recapitulate various studies on the role of free radicals in DNA damage-both nuclear as well as mitochondrial-the oxidative stress they impose on cells, the role of antioxidants, the presence of autoantibodies, and their overall impact on the aging process.

摘要

有300多种理论来解释衰老现象。其中许多理论源于对随时间积累的变化的研究。在所有理论中，由哈曼首次提出的衰老自由基理论是最流行且经过广泛验证的，它基于自由基的化学性质及其普遍存在。本综述旨在概述关于自由基在DNA损伤（包括细胞核和线粒体DNA损伤）中的作用、它们对细胞施加的氧化应激、抗氧化剂的作用、自身抗体的存在及其对衰老过程的总体影响的各种研究。