Paulson D S, Fendler E J, Dolan M J, Williams R A
BioScience Laboratories, Inc, Bozeman, Montana, USA.
Am J Infect Control. 1999 Aug;27(4):332-8. doi: 10.1016/s0196-6553(99)70053-2.
Hand transmission of microbes by health care workers is a primary cause of nosocomial infections in both long-term and acute care facilities. Compliance with effective handwashing and hand sanitization regimens can break this cycle.
We investigated the antimicrobial efficacy and irritation potential of 5 handwash product regimens: a nonantimicrobial lotion soap, an antimicrobial lotion soap, an alcohol gel sanitizer, a nonantimicrobial lotion soap with an alcohol gel sanitizer, and an antimicrobial lotion soap with an alcohol gel sanitizer. The regimens were evaluated by using a Healthcare Personnel Handwash procedure, and irritation was assessed by using expert hand evaluation after 25 consecutive washes.
The Healthcare Personnel Handwash data showed that the mean log reductions from baseline were greatest for the lotion soaps with alcohol gel sanitizer, less for the alcohol and the antimicrobial soap alone, and least for the bland soap. All of the product regimens showed a low potential for skin irritation.
In terms of both microorganism reduction and skin irritation, the most effective product regimens were the use of alcohol gel sanitizer in combination with either an antimicrobial or a plain lotion soap.
医护人员通过手部传播微生物是长期护理机构和急症护理机构中医院感染的主要原因。遵守有效的洗手和手部消毒方案可以打破这一循环。
我们调查了5种洗手产品方案的抗菌效果和刺激可能性：一种非抗菌乳液皂、一种抗菌乳液皂、一种酒精凝胶消毒剂、一种搭配酒精凝胶消毒剂的非抗菌乳液皂，以及一种搭配酒精凝胶消毒剂的抗菌乳液皂。通过使用医护人员洗手程序对这些方案进行评估，并在连续洗手25次后通过专家手部评估来评估刺激情况。
医护人员洗手数据显示，搭配酒精凝胶消毒剂的乳液皂从基线开始的平均对数减少量最大，单独使用酒精和抗菌皂的减少量较小，而普通肥皂的减少量最小。所有产品方案对皮肤的刺激可能性都较低。
在减少微生物和皮肤刺激方面，最有效的产品方案是将酒精凝胶消毒剂与抗菌或普通乳液皂联合使用。
