Almirantis Y, Papageorgiou S
N.C.S.R. "Demokritos" 153 10 Ag. Paraskevi Attikis, Athens, Greece.
J Theor Biol. 1999 Aug 7;199(3):235-42. doi: 10.1006/jtbi.1999.0954.
Diffusing morphogens in cooperation can control gene expression in developing limbs. Additive cooperation corresponds to the Boolean operator OR and implies the equivalent action of the (suitably scaled) concentrations of two morphogens, either by their alternative binding to the same receptor or by another way of convergence of their effects during the signal transduction procedure. This cooperation can explain the spatial and temporal collinearities of the expression of hoxd genes in the vertebrate limb bud. A multiplicative cooperation of morphogens (corresponding to the Boolean operator AND), produced at the DPP and WG domains in the Drosophila leg imaginal disc, may account for the expression domains observed for Dll and dac. A molecular interpretation of the multiplicative morphogen cooperation is proposed. Some experiments are suggested for further testing of the model.
扩散的形态发生素协同作用可控制发育中肢体的基因表达。加性协同作用对应于布尔运算符“或”，意味着两种形态发生素（适当缩放后的）浓度具有等效作用，要么是它们交替结合同一受体，要么是在信号转导过程中通过另一种效应汇聚方式。这种协同作用可以解释脊椎动物肢体芽中hoxd基因表达的时空共线性。果蝇腿部成虫盘DPP和WG区域产生的形态发生素的乘性协同作用（对应于布尔运算符“与”），可能解释了Dll和dac的表达域现象。本文提出了对乘性形态发生素协同作用的分子解释。还提出了一些实验以进一步检验该模型。
