Mglinets V A
Genetika. 1993 Nov;29(11):1765-83.
The data are surveyed concerning formation of limb buds in Vertebrate, development of morphogenetic fields in limb buds, their organization based on the simple gradient model and the model of polar coordinates. Formation of the morphogenetic fields of strictly located events, such as chondrogenesis and prescheduled cell death, based on the positional information is discussed. All the stages of limb formation in Vertebrate are under genetic control, the products of some genes behaving as extracellular factors (morphogens) and those of other as cell receptors or transcriptional factors inducing activity of specific gene sets. Highly important at that are regulatory homeobox genes.
研究了脊椎动物肢体芽的形成、肢体芽中形态发生场的发育、基于简单梯度模型和极坐标模型的组织方式。讨论了基于位置信息形成严格定位事件的形态发生场，如软骨形成和预定细胞死亡。脊椎动物肢体形成的所有阶段都受基因控制，一些基因的产物表现为细胞外因子（形态发生素），另一些基因的产物则表现为细胞受体或诱导特定基因集活性的转录因子。其中非常重要的是调控性同源框基因。
