Dupont J, Tavernier B, Ghosez Y, Durinck L, Thevenot A, Moktadir-Chalons N, Ruyffelaere-Moises L, Declerck N, Scherpereel P
Département d'Anesthésie Réanimation Chirurgicale II, CHRU, Lille, France.
Br J Anaesth. 1999 Mar;82(3):355-9. doi: 10.1093/bja/82.3.355.
We have studied maintenance and recovery profiles after general anaesthesia with sevoflurane, desflurane and isoflurane in 100 patients undergoing pulmonary surgery. End-tidal concentrations of anaesthetic required to maintain mean arterial pressure and heart rate within 20% of baseline values were 1.4 +/- 0.6% for sevoflurane, 3.4 +/- 0.9% for desflurane and 0.7 +/- 0.3% for isoflurane. The three anaesthetics had comparable haemodynamic effects and arterial oxygenation during one-lung ventilation. Emergence was twice as fast with desflurane than with sevoflurane or isoflurane (mean times to extubation: 8.9 (SD 5.0) min, 18.0 (17.0) min and 16.2 (11.0) min for desflurane, sevoflurane and isoflurane, respectively). Early recovery (Aldrete score, cognitive and psychomotor functions) was also more rapid after desflurane. In pulmonary surgery, desflurane, but not sevoflurane, allowed more rapid emergence and earlier recovery than isoflurane.
我们研究了100例接受肺部手术的患者在使用七氟醚、地氟醚和异氟醚进行全身麻醉后的维持和恢复情况。维持平均动脉压和心率在基线值的20%以内所需的呼气末麻醉药浓度，七氟醚为1.4±0.6%，地氟醚为3.4±0.9%，异氟醚为0.7±0.3%。在单肺通气期间，这三种麻醉药具有相似的血流动力学效应和动脉氧合作用。地氟醚的苏醒速度是七氟醚或异氟醚的两倍（拔管平均时间：地氟醚为8.9（标准差5.0）分钟，七氟醚为18.0（17.0）分钟，异氟醚为16.2（11.0）分钟）。地氟醚麻醉后的早期恢复（Aldrete评分、认知和精神运动功能）也更快。在肺部手术中，与异氟醚相比，地氟醚（而非七氟醚）能实现更快的苏醒和更早的恢复。
