Dua H S, Azuara-Blanco A
Department of Ophthalmology, Queen's Medical Centre, University Hospital, Nottingham.
Br J Ophthalmol. 1999 Apr;83(4):414-9. doi: 10.1136/bjo.83.4.414.
To report the outcome of a series of patients with stem cell deficiency who underwent allo-limbal transplantation and to describe a technique for this procedure.
Six consecutive patients underwent allo-limbal stem cell transplantation. The primary diagnosis included alkali burn (n = 2), trachoma (n = 1), chronic rosacea blepharitis and kerato-conjunctivitis (n = 1), aniridia (n = 1), and Stevens-Johnson syndrome (n = 1). The limbal rim consisted of peripheral cornea and perilimbal sclera. FK-506 was used postoperatively for immunosuppression.
The length of follow up ranged from 3 to 24 months (mean follow up 11.8 (SD 9.3) months). The outcome was considered satisfactory in five of six cases. The corneal surface was completely epithelialised within 2 weeks, and there was a substantial improvement in vision and symptoms. One patient had recurrent epithelial defects related to eyelid abnormalities. No side effects associated with systemic immunosuppression were noted.
Allo-limbal transplantation, with systemic immunosuppression with FK-506 is useful in reconstruction of the ocular surface with improvement in vision in patients with severe stem cell deficiency.
报告一系列接受同种异体角膜缘移植的干细胞缺乏患者的治疗结果，并描述该手术的一种技术。
连续6例患者接受了同种异体角膜缘干细胞移植。主要诊断包括碱烧伤（2例）、沙眼（1例）、慢性酒渣鼻性睑缘炎和角膜结膜炎（1例）、无虹膜（1例）以及史蒂文斯-约翰逊综合征（1例）。角膜缘环由周边角膜和角巩膜缘组成。术后使用FK-506进行免疫抑制。
随访时间为3至24个月（平均随访11.8（标准差9.3）个月）。6例中有5例结果令人满意。角膜表面在2周内完全上皮化，视力和症状有显著改善。1例患者因眼睑异常出现复发性上皮缺损。未观察到与全身免疫抑制相关的副作用。
同种异体角膜缘移植联合FK-506全身免疫抑制对严重干细胞缺乏患者的眼表重建及视力改善有效。
