Chung H S, Harris A, Kagemann L, Martin B
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 4602-6195, USA.
Br J Ophthalmol. 1999 Apr;83(4):466-9. doi: 10.1136/bjo.83.4.466.
To determine if normal tension glaucoma (NTG) patients differ from age matched controls in blood flow to the peripapillary retina, as measured with confocal scanning laser Doppler flowmetry (cSLDF; "Heidelberg retinal flowmetry").
12 NTG patients and 12 age matched controls were compared using (a) 10 x 10 pixel boxes (the instrument default sample size), taken from the nasal and temporal peripapillary retina, (b) the average from two of these boxes, and (c) every qualifying pixel within the peripapillary retina.
Patients and controls did not differ in blood flow measured using the default sample from a single 10 x 10 pixel box, placed in either the temporal or nasal peripapillary retina, or expressed as the average from these two boxes. However, in histograms using every pixel from the peripapillary retina, NTG patients displayed significantly higher percentages of minimal flow pixels (defined as less than one arbitrary unit of flow: 30% v 19%, p < 0.01), and significantly lower flow in the 25th, 50th, and 75th percentile flow pixel (each p < 0.05) than did age matched controls.
NTG is characterised by reduced blood flow in the peripapillary retina, a result suggesting that blood flow deficits accompany, and perhaps may contribute to, disease development in these patients.
使用共焦扫描激光多普勒血流仪（cSLDF；“海德堡视网膜血流仪”）测量，确定正常眼压性青光眼（NTG）患者与年龄匹配的对照组在视乳头周围视网膜血流方面是否存在差异。
对12例NTG患者和12例年龄匹配的对照组进行比较，采用（a）从视乳头周围视网膜鼻侧和颞侧获取的10×10像素框（仪器默认样本大小），（b）其中两个框的平均值，以及（c）视乳头周围视网膜内每个合格像素。
使用放置在颞侧或鼻侧视乳头周围视网膜的单个10×10像素框的默认样本测量的血流，患者和对照组之间没有差异，也没有表现为这两个框的平均值。然而，在使用视乳头周围视网膜每个像素的直方图中，NTG患者显示最小血流像素的百分比显著更高（定义为血流小于一个任意单位：30%对19%，p<0.01），并且在第25、50和75百分位数血流像素中的血流显著低于年龄匹配的对照组（每个p<0.05）。
NTG的特征是视乳头周围视网膜血流减少，这一结果表明血流不足伴随着这些患者的疾病发展，并且可能对疾病发展有影响。
