O'Brart D P, de Souza Lima M, Bartsch D U, Freeman W, Weinreb R N
Glaucoma Center, University of California at San Diego, La Jolla 92093-0946, USA.
Am J Ophthalmol. 1997 May;123(5):657-66. doi: 10.1016/s0002-9394(14)71078-5.
To investigate the peripapillary region in glaucomatous eyes by indocyanine green angiography.
Indocyanine green angiography of the optic disk and peripapillary region was evaluated by modified confocal scanning laser ophthalmoscopy in 22 eyes of 22 patients with glaucoma and in 10 normal eyes of 10 control patients with unilateral choroidal melanoma. The occurrence and extent of indocyanine green angiographic anomalies were correlated with optic disk morphology and the severity of glaucoma.
In the 32 eyes of 32 patients, two types of peripapillary defects were identified in the late-phase angiograms. The first was hypofluorescent areas in the peripapillary region and was more common in eyes with glaucoma (P < .02); their occurrence and extent correlated with age (P < .01). In nine of the 17 eyes, alpha (peripheral) zone peripapillary atrophy corresponded with the areas of peripapillary indocyanine green hypofluorescene. The second defect, hypofluorescent halos adjacent to and extending around the full circumference of the optic disk margins, did not correlate with any of the study factors.
Indocyanine green angiography showed areas of hypofluorescene in the peripapillary region in late-phase angiograms in 68% of glaucomatous eyes compared with 20% of control eyes. These hypofluorescent areas might be either of result of blockage of background fluorescence by pigment or caused by an absence of vascular tissue (choriocapillaris).
通过吲哚菁绿血管造影术研究青光眼患者的视盘周围区域。
采用改良的共焦扫描激光检眼镜对22例青光眼患者的22只眼和10例单侧脉络膜黑色素瘤对照患者的10只正常眼进行视盘和视盘周围区域的吲哚菁绿血管造影。将吲哚菁绿血管造影异常的发生情况和范围与视盘形态及青光眼严重程度进行相关性分析。
在32例患者的32只眼中，在晚期血管造影片中发现了两种类型的视盘周围缺损。第一种是视盘周围区域的低荧光区，在青光眼眼中更为常见（P <.02）；其发生情况和范围与年龄相关（P <.01）。在17只眼中的9只，视盘周围α（周边）区萎缩与视盘周围吲哚菁绿低荧光区相对应。第二种缺损是与视盘边缘全周相邻并环绕其延伸的低荧光晕，与任何研究因素均无相关性。
与20%的对照眼相比，68%的青光眼眼在晚期血管造影片中视盘周围区域出现低荧光区。这些低荧光区可能是由于色素对背景荧光的遮挡，或者是由于血管组织（脉络膜毛细血管）缺失所致。
