Prim M P, De Diego J I, Hardisson D, Madero R, Nistal M, Gavilán J
Department of Otorhinolaryngology, La Paz Hospital, Autonomous University, Madrid, Spain.
Ann Otol Rhinol Laryngol. 1999 Jul;108(7 Pt 1):672-6. doi: 10.1177/000348949910800710.
The influence of extracapsular spread (ECS) and a desmoplastic pattern (DP) of metastatic cervical lymph nodes in patients with laryngeal cancer is presented. The study includes 128 patients surgically treated between 1984 and 1992 for squamous cell carcinoma of the larynx with pathologically proven lymph node metastasis. The results were studied from 2 major standpoints: survival and recurrence. The 3-year survival rates were as follows: patients without ECS 73.4%, and with ECS 28.9% (p < .001); patients without a DP 76.9%, and with a DP 43.3% (p < .03). Also, the 3-year recurrence rates in the neck showed significant differences: patients without ECS 10.7%, and with ECS 49.6% (p < .001); patients without a DP 10%, and with a DP 31.6% (p = .1142). Postoperative radiotherapy did not appear to improve the outcome.
本文介绍了喉癌患者转移性颈部淋巴结的包膜外扩散（ECS）和促结缔组织增生模式（DP）的影响。该研究纳入了1984年至1992年间接受手术治疗的128例喉鳞状细胞癌患者，这些患者均有病理证实的淋巴结转移。从生存和复发这两个主要角度对结果进行了研究。3年生存率如下：无ECS的患者为73.4%，有ECS的患者为28.9%（p <.001）；无DP的患者为76.9%，有DP的患者为43.3%（p <.03）。此外，颈部的3年复发率也存在显著差异：无ECS的患者为10.7%，有ECS的患者为49.6%（p <.001）；无DP的患者为10%，有DP的患者为31.6%（p = 0.1142）。术后放疗似乎并未改善预后。
