Enríquez R, Rondini C, Sánchez A, Montes C, Poblete J A, Neira J, Oyarzún E, Germain A
Departamento de Obstetricia y Ginecología, Escuela de Medicina, Pontificia Universidad Católica de Chile.
Rev Med Chil. 1999 Feb;127(2):171-80.
We report 10 patients with congenital deficiencies of the natural anticoagulant proteins S, C and antithrombin III. Thirteen of a total of 30 pregnancies were managed at the perinatal branch of our department. We discuss the mechanism of action of these proteins and their role in thrombotic events. We analyze the most frequent thrombotic complications and we discuss the general guidelines for the investigation of a patient with a suspected congenital thrombophilia with special regard to its management during pregnancy, delivery and perinatal outcome.
我们报告了10例先天性天然抗凝蛋白S、C和抗凝血酶III缺乏的患者。在我们科室的围产期分支处理了总共30次妊娠中的13次。我们讨论了这些蛋白的作用机制及其在血栓形成事件中的作用。我们分析了最常见的血栓形成并发症，并讨论了对疑似先天性血栓形成倾向患者进行检查的一般指导原则，特别关注其在妊娠、分娩和围产期结局期间的管理。
