Bhattacharyya Maitreyee, Kannan M, Chaudhry V P, Saxena Renu
Department of Hematology, All India Institute of Medical Sciences, New Delhi.
Indian J Pathol Microbiol. 2003 Oct;46(4):621-4.
431 patients with thrombosis of different venous system were evaluated for underlying acquired and inherited prothrombotic states. Associated acquired risk factors were observed to be present in 28.7% patients and possible inherited in 32.3%, in the rest, no cause could be identified. Major acquired risk factors included coexistence of liver disease (12.2%), oral contraceptives (4.1%), puerperium (2.5%), malignancy (2.3%) and lupus anticoagulant (2%). Low levels of protein C were detected in 21.1% and of which 11.3% were attributed to acquired factors. Protein S deficiency was found in 19.0% and of these 10.4% cases were associated with acquired risk factors. Antithrombin III (AT III) deficiency was detected in 6.4% of patients, of which 4.8% were secondary to acquired factors. In the rest, deficiency of protein C, protein S and AT III were attributed to inherited factors as no associated acquired risk factor was present. Activated protein C resistance (APC-R) was present in 12.5% cases.
对431例不同静脉系统血栓形成的患者进行了潜在获得性和遗传性血栓前状态的评估。观察到28.7%的患者存在相关获得性危险因素，32.3%的患者可能存在遗传性危险因素，其余患者未发现病因。主要的获得性危险因素包括肝病并存（12.2%）、口服避孕药（4.1%）、产褥期（2.5%）、恶性肿瘤（2.3%）和狼疮抗凝物（2%）。21.1%的患者检测到蛋白C水平降低，其中11.3%归因于获得性因素。发现19.0%的患者存在蛋白S缺乏，其中10.4%的病例与获得性危险因素有关。6.4%的患者检测到抗凝血酶III（AT III）缺乏，其中4.8%继发于获得性因素。其余患者中，蛋白C、蛋白S和AT III缺乏归因于遗传因素，因为不存在相关的获得性危险因素。12.5%的病例存在活化蛋白C抵抗（APC-R）。
