D'Erasmo E, Pisani D, Ragno A, Raejntroph N, Letizia C, Acca M
II Clinica Medica, Policlinico Umberto I, Università La Sapienza, Roma, Italia.
Horm Metab Res. 1999 Jun;31(6):385-8. doi: 10.1055/s-2007-978760.
Some discrepancies exist about the relationship between serum albumin level and the pathogenesis of osteoporosis; moreover, most of the studies available have especially concerned patients with osteoporosis, often associated with fractures. Our study, therefore, aims to investigate the presence of a relationship between serum albumin level and bone mineral density in a group of healthy women (n=650; mean age 59.0 +/- 7.4 years) who voluntarily underwent screening for osteoporosis only because they were menopausal (11.2 +/- 7.4 years since menopause) and, for comparison, in a group of outpatients (n = 44; mean age 57.6 +/- 7.0 years; 9.1 +/- 6.7 years since menopause) with hypoalbuminemia associated with diseases. The results show a lack of any relationship in healthy women between serum albumin value and bone mineral density; the lack of correlation was also shown when the postmenopausal women were down into normal, osteopenic and osteoporotic (WHO criteria) or in hypo, normal and hyperalbuminemic. The only significant parameters associated with lower bone mineral density, in fact, were age and years since menopause (p<0.0001 and p<0.0001 respectively at lumbar spine and p<0.02 and p<0.001 at femoral neck level). In the group of patients with hypoalbuminemia associated with diseases, on the other hand, a relationship between reduced bone mineral density and hypoalbuminemia was found (p<0.01 and p<0.05 respectively at lumbar spine and femoral neck). In conclusion, in healthy postmenopausal women the serum albumin level does not play a significant role in the pathogenesis of bone density reduction, which is mainly due to the number of years since menopause and advancing age. The hypoalbuminemia may be related to the reduction of bone mass only in the subjects affected by diseases associated with a significant albumin reduction.
血清白蛋白水平与骨质疏松症发病机制之间的关系存在一些差异；此外，现有的大多数研究特别关注患有骨质疏松症且常伴有骨折的患者。因此，我们的研究旨在调查一组健康女性（n = 650；平均年龄59.0±7.4岁）血清白蛋白水平与骨密度之间的关系，这些女性仅因处于绝经期（绝经后11.2±7.4年）而自愿接受骨质疏松症筛查，作为比较，还调查了一组患有与疾病相关的低白蛋白血症的门诊患者（n = 44；平均年龄57.6±7.0岁；绝经后9.1±6.7年）。结果显示，健康女性的血清白蛋白值与骨密度之间不存在任何关系；当将绝经后女性按照正常、骨量减少和骨质疏松（世界卫生组织标准）或低白蛋白血症、正常白蛋白血症和高白蛋白血症进行分类时，也显示出缺乏相关性。事实上，与较低骨密度相关的唯一显著参数是年龄和绝经年限（腰椎处分别为p<0.0001和p<0.0001，股骨颈处为p<0.02和p<0.001）。另一方面，在患有与疾病相关的低白蛋白血症的患者组中，发现骨密度降低与低白蛋白血症之间存在关系（腰椎和股骨颈处分别为p<0.01和p<0.05）。总之，在健康的绝经后女性中，血清白蛋白水平在骨密度降低的发病机制中不发挥重要作用，骨密度降低主要归因于绝经年限和年龄增长。低白蛋白血症可能仅与患有导致白蛋白显著降低疾病的受试者的骨量减少有关。
