Li Yuancheng, Qi Huaqian, Huang Xin, Lu Gang, Pan Huashan
Clinical Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
School of Physical Education and Health, Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Physiol. 2024 May 31;15:1411148. doi: 10.3389/fphys.2024.1411148. eCollection 2024.
Recent epidemiological studies and animal experiments have highlighted the significant role of oxidative stress in the development of osteoporosis (OP). The provision of antioxidants is widely considered a fundamental strategy to combat free radical-induced stress, inhibit oxidative damage, and potentially reverse the adverse effects of oxidative stress on bone health. However, there is no consensus in the scientific literature regarding the practical effectiveness of antioxidants in OP prevention and treatment. Some studies have not shown a clear connection between antioxidant supplementation and decreased OP risk. Therefore, it is essential to clarify the potential causal relationship between antioxidants and the development of OP.
The study utilized the inverse variance weighted (IVW) approach as the primary analytical method in the Mendelian Randomization (MR) framework to investigate the causal effects of five exogenous and six endogenous antioxidants on the risk of OP. To thoroughly assess potential pleiotropic effects and heterogeneity among the data analyzed, the MR-Egger intercept test was employed, and Cochran's Q statistic was calculated.
In the evaluation of exogenous antioxidants, single-directional two-sample MR analyses did not reveal any statistically significant relationship between these agents and the risk of OP. Regarding endogenous antioxidants, bidirectional two-sample MR analyses were conducted, which generally indicated that most genetically regulated endogenous antioxidants had no significant association with the onset risk of OP. A significant causal relationship was found between OP and serum albumin levels (: -0.0552, 95%CI: -0.0879 to -0.0225, 0.0011 after Bonferroni adjustment, power = 100%).
The research uncovers OP as a possible determinant contributing to a decrement in serum albumin levels, and further suggests a potentially intimate relationship between the downward trajectory of serum albumin concentrations and the advancement of the OP disease process.
近期的流行病学研究和动物实验突出了氧化应激在骨质疏松症（OP）发展中的重要作用。提供抗氧化剂被广泛认为是对抗自由基诱导的应激、抑制氧化损伤以及潜在逆转氧化应激对骨骼健康不利影响的基本策略。然而，关于抗氧化剂在OP预防和治疗中的实际效果，科学文献中尚未达成共识。一些研究并未显示补充抗氧化剂与降低OP风险之间存在明确联系。因此，明确抗氧化剂与OP发展之间的潜在因果关系至关重要。
本研究采用逆方差加权（IVW）方法作为孟德尔随机化（MR）框架中的主要分析方法，以研究五种外源性和六种内源性抗氧化剂对OP风险的因果效应。为全面评估所分析数据中的潜在多效性效应和异质性，采用了MR-Egger截距检验，并计算了Cochran's Q统计量。
在外源性抗氧化剂的评估中，单向双样本MR分析未发现这些物质与OP风险之间存在任何统计学上的显著关系。对于内源性抗氧化剂，进行了双向双样本MR分析，总体表明大多数基因调控的内源性抗氧化剂与OP的发病风险无显著关联。发现OP与血清白蛋白水平之间存在显著因果关系（：-0.0552，95%CI：-0.0879至-0.0225，经Bonferroni校正后 0.0011，效能 = 100%）。
该研究发现OP可能是导致血清白蛋白水平下降的一个决定因素，并进一步表明血清白蛋白浓度下降轨迹与OP疾病进程进展之间可能存在密切关系。
