Larsson N G, Luft R
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
FEBS Lett. 1999 Jul 23;455(3):199-202. doi: 10.1016/s0014-5793(99)00854-6.
A revolution in chemical pathology occurred about 40 years ago with the discovery of a patient with mitochondrial dysfunction. The field of mitochondrial medicine has experienced explosive growth during the last decade. More than 50 mtDNA mutations and several nuclear gene mutations have been identified in affected patients. The recent development of animal models will continue the revolution in mitochondrial medicine by facilitating in depth studies of the molecular pathogenesis and development of novel drug and gene therapy strategies for mitochondrial dysfunction. As we enter the next millennium, we can expect mitochondrial medicine to remain a dynamic and rapidly developing field.
大约40年前，随着一名线粒体功能障碍患者的发现，化学病理学领域发生了一场革命。在过去十年中，线粒体医学领域经历了爆炸式增长。在受影响的患者中已鉴定出50多种线粒体DNA突变和几种核基因突变。动物模型的最新发展将通过促进对分子发病机制的深入研究以及开发针对线粒体功能障碍的新型药物和基因治疗策略，继续推动线粒体医学的革命。随着我们进入下一个千年，我们可以预期线粒体医学仍将是一个充满活力且快速发展的领域。
