Lyness J M, Caine E D, King D A, Conwell Y, Cox C, Duberstein P R
Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA.
Am J Geriatr Psychiatry. 1999 Summer;7(3):252-8. doi: 10.1097/00019442-199908000-00010.
The authors examined whether cerebrovascular risk factors (CVRFs) are associated with depressive diagnoses and symptoms in 303 primary-care patients age >/=60 years, as would be consistent with a small-vessel brain disease model of later-life depression. CVRFs were not significantly independently associated with major, minor, or subsyndromal depression, late-onset major depression, or overall depressive symptom severity. These data did not support the notion that a small-vessel brain disease model of depression might apply to the majority of older persons with depressive symptoms and syndromes in primary-care settings. Future work should include longitudinal study with larger sample sizes.
作者们研究了脑血管危险因素（CVRFs）是否与303名年龄≥60岁的初级保健患者的抑郁诊断及症状相关，这与晚年抑郁症的小血管脑疾病模型相一致。CVRFs与重度、轻度或亚综合征性抑郁、晚发性重度抑郁或总体抑郁症状严重程度并无显著独立关联。这些数据并不支持抑郁症的小血管脑疾病模型可能适用于初级保健环境中大多数有抑郁症状和综合征的老年人这一观点。未来的研究应包括更大样本量的纵向研究。
