Dosenko V Ie
A. A. Bogomolets National Medical University, Kiev.
Fiziol Zh (1994). 1999;45(3):43-51.
The role of the elastolytic system arterial and venous tissues in pathogenesis of vascular pathology was investigated on rabbits and rats in experimental arterio-atherosclerosis. The obtained results indicate that elastase activity in aortic homogenates was significant higher in normal and pathological condition in rats than in rabbits. Elastase inhibitors (alpha 2-macroglobulin and alpha 1-proteinase inhibitor) also respond on angiosclerotic agent and level of alpha 2-macroglobulin increased significant in resistant animals (rats) but not in rabbits. In venous vessels determined more higher level of antielastase potential that may be explain its phenomenal resistance to different damage factors. The presented result confirm the importance of balance elastase and it inhibitors in pathogenesis of arterio-atherosclerosis.
在实验性动脉粥样硬化的兔子和大鼠身上，研究了弹性蛋白酶系统在动脉和静脉组织血管病变发病机制中的作用。所得结果表明，在正常和病理状态下，大鼠主动脉匀浆中的弹性蛋白酶活性显著高于兔子。弹性蛋白酶抑制剂（α2-巨球蛋白和α1-蛋白酶抑制剂）也对血管硬化剂有反应，在抗性动物（大鼠）中α2-巨球蛋白水平显著升高，但在兔子中没有。在静脉血管中测定的抗弹性蛋白酶潜力水平更高，这可能解释了其对不同损伤因素的显著抗性。所呈现的结果证实了弹性蛋白酶及其抑制剂的平衡在动脉粥样硬化发病机制中的重要性。
