Kasai K, Nakagome K, Itoh K, Koshida I, Hata A, Iwanami A, Fukuda M, Hiramatsu K I, Kato N
Department of Neuropsychiatry, Faculty of Medicine, Graduate School of Medicine, University of Tokyo.
Neuroreport. 1999 Aug 2;10(11):2267-71. doi: 10.1097/00001756-199908020-00008.
To reveal the spatiotemporal characteristics of the auditory automatic discrimination process, mismatch negativity (MMN) generators were assessed with a high-resolution EEG system (128ch) and scalp current density (SCD) analysis. Ten normal volunteers participated in the study. Event-related potentials were recorded during a selective attention task. Sequential SCD mappings revealed that a current sink/source combination in the left temporal regions and a current sink in the right frontotemporal regions appeared around 200 msec irrespective of the ear of stimulation. Moreover, a parietal sink/source combination was demonstrated on the right hemisphere around 240 ms irrespective of the ear of stimulation. These findings demonstrate that the auditory automatic change detection process is, both spatially and temporally, a multiple-generated system.
为揭示听觉自动辨别过程的时空特征，采用高分辨率脑电图系统（128导）和头皮电流密度（SCD）分析评估失匹配负波（MMN）发生器。10名正常志愿者参与了该研究。在选择性注意任务期间记录事件相关电位。连续的SCD映射显示，无论刺激耳是哪一侧，左颞区的电流汇/源组合以及右额颞区的电流汇在约200毫秒左右出现。此外，无论刺激耳是哪一侧，右半球顶叶在约240毫秒左右出现电流汇/源组合。这些发现表明，听觉自动变化检测过程在空间和时间上都是一个多发生器系统。
