Grinspan D, Abulafia J, Lanfranchi H
Department of Dermatology, Hospital de Clínicas, University of Buenos Aires School of Medicine, Argentina.
Int J Dermatol. 1999 Jul;38(7):525-8. doi: 10.1046/j.1365-4362.1999.00682.x.
In 1967, Badham used the term angina bullosa hemorrhagica (ABH) to describe an entity we already knew as traumatic oral hemophlyctenosis (TOH) (1933) and later renamed recurrent oral hemophlyctenosis (ROH) (1971).
The objective of this study was to review and discuss the literature, and to report 54 new cases seen between 1989 and 1996.
Fifty-four patients were thoroughly assessed to determine the clinical features, histology, etiology, pathogenesis, differential diagnosis, and therapy.
In 35 patients (64.8%), the lesions predominated on the palate and in nine (16.6%) on the oral mucosa. The incidence was similar in both sexes (women, 52%; men, 48%) and the condition affected mostly the 51-70-year age group. ABH was never documented in children under 10 years of age. In 24 cases (44.4%), diabetes mellitus, hyperglycemia, and/or a family history of diabetes was found.
ABH is a disorder more common than the literature would suggest. Although the causes may be multiple (mucosal trauma, inhaled corticosteroids), the available data indicate that, in these patients, the presence of an alteration in glucose metabolism should be considered.
1967年，巴德姆使用“出血性大疱性心绞痛（ABH）”这一术语来描述一种我们已经熟知的疾病，即创伤性口腔血疱病（TOH）（1933年），后来又将其重新命名为复发性口腔血疱病（ROH）（1971年）。
本研究的目的是回顾和讨论相关文献，并报告1989年至1996年间新发现的54例病例。
对54例患者进行了全面评估，以确定其临床特征、组织学、病因、发病机制、鉴别诊断和治疗方法。
在35例患者（64.8%）中，病变主要发生在腭部，9例（16.6%）发生在口腔黏膜。男女发病率相似（女性52%；男性48%），该疾病主要影响51至70岁年龄组。10岁以下儿童从未有过ABH的记录。在24例患者（44.4%）中，发现患有糖尿病、高血糖和/或有糖尿病家族史。
ABH是一种比文献报道更为常见的疾病。尽管病因可能是多方面的（黏膜创伤、吸入性糖皮质激素），但现有数据表明，对于这些患者，应考虑存在糖代谢改变的情况。
