Ghaemi S N, Goodwin F K
Center on Neuroscience, Medical Progress, and Society, Department of Psychiatry, George Washington University, Washington, DC, USA.
J Clin Psychopharmacol. 1999 Aug;19(4):354-61. doi: 10.1097/00004714-199908000-00012.
Atypical antipsychotic agents seem to be effective treatments for bipolar disorder, especially as adjunctive treatments. They may be a safer and more effective alternative to the common practice of maintenance adjunctive treatment with traditional antipsychotic agents in patients with bipolar disorder. However, currently available research studies are limited methodologically mainly to open-label, uncontrolled designs. Further research is required before the definitive efficacy of these agents in bipolar disorder is established. If randomized or double-blind data support the open-label data reviewed here, atypical antipsychotic agents may possess an important role in the adjunctive treatment of bipolar disorder.
非典型抗精神病药物似乎是治疗双相情感障碍的有效方法，尤其是作为辅助治疗。对于双相情感障碍患者，与传统抗精神病药物进行维持辅助治疗的常规做法相比，它们可能是一种更安全、更有效的替代方法。然而，目前可用的研究在方法上主要局限于开放标签、无对照的设计。在确定这些药物对双相情感障碍的确切疗效之前，还需要进一步研究。如果随机或双盲数据支持此处回顾的开放标签数据，非典型抗精神病药物可能在双相情感障碍的辅助治疗中发挥重要作用。
