De Petrocellis L, Orlando P, Pierobon P, De Falco M, Ruggiero A M, Stefano G S, Tino A, Grippo P
Institute of Cibernetica, C.N.R., Napoli, Italia.
Res Commun Mol Pathol Pharmacol. 1999 Jan;103(1):17-28.
The effects of kelletinin A [ribityl pentakis (p-hydroxybenzoate)] (KA), a natural compound isolated from the marine gastropod Buccinulum corneum, were studied in vivo in Hydra vulgaris during regeneration. KA caused a marked increase of regenerated tentacle numbers (ATN) and promoted transdifferentiation of epithelial cells into battery cells, and nematocyte differentiation. Morphological data were correlated to changes in acid and alkaline phosphatase levels, enzymes that have been described as regeneration markers.
从海洋腹足纲动物角质滨螺中分离出的一种天然化合物——凯勒亭宁A核糖基五（对羟基苯甲酸酯），在普通水螅再生过程中进行了体内研究。KA导致再生触手数量显著增加（ATN），并促进上皮细胞向电池细胞的转分化以及刺细胞的分化。形态学数据与酸性和碱性磷酸酶水平的变化相关，这两种酶已被描述为再生标志物。
